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A trial was about to launch for a vaccine that would ward off the HIV virus. It would be an incredible breakthrough. Then it looked as if it would be over before it started.

(Image credit: Tommy Trenchard for NPR)

The Administration for a Healthy America is RFK Jr.'s plan to tackle chronic disease, addiction and other persistent problems. But so far it's not being set up like previous new agencies.

(Image credit: Alex Wong)

Minneapolis is at the center of sweeping, evolving federal immigration push. It demonstrates how different immigration enforcement is under Trump's second administration - and raises questions about the lingering effects on local communities and law enforcement.

(Image credit: Adam Gray/AP)

Prediction market apps are thriving in Trump's second term, with traders betting on migrant deportations to election outcomes. A community of young, mostly male and very online traders are driving the industry's bonanza.

(Image credit: Evan Frost for NPR and Meredith Nierman/NPR)

The crew of USS Ford is struggling to handle sewage problems on board the Navy's newest carrier.

(Image credit: Paige Brown)

President Trump says he's cutting federal money to sanctuary cities. But courts have blocked similar moves, ruling that the federal government can't use funding to coerce state and local governments.

(Image credit: John Locher)

Officers in the Minneapolis-area participating in a U.S. immigration enforcement operation can't detain or tear gas peaceful protesters who aren't obstructing authorities, a judge ruled Friday.

(Image credit: John Locher)

Federal prosecutors are investigating Gov. Tim Walz and Mayor Jacob Frey.

(Image credit: Stephen Maturen)

A Iran returns to an uneasy calm after protests led to a violent crackdown, a senior cleric is calling for the death penalty for detained demonstrators. His sermon Friday also threatened U.S. President Trump.

(Image credit: Ebrahim Noroozi)

Minneapolis residents are resisting as federal immigration agents surge into their city, creating what some locals describe as an atmosphere of fear and siege on the streets.

More than 550 people have contracted measles in Spartanburg County, S.C., in a fast-growing outbreak. Like a majority of U.S. counties, nonmedical exemptions to school vaccination are also rising.

(Image credit: Ken Ruinard)

Abigail Spanberger, a former CIA officer and three-term congresswoman, is breaking long-held traditions on inauguration day. She says she wants her swearing-in to showcase the state's modern vibrancy.

(Image credit: Tyrone Turner)

Many jails and prisons around the country don't provide medication treatment for opioid use disorder. Studies show that medication makes recovery more likely and reduces the risk of overdose death.

(Image credit: Ash Adams for NPR)

This is a short update on the Planet Money Board Game project.

All 16 drug companies that inked deals with the Trump administration over the past few months still raised some of their prices for 2026.

(Image credit: Win McNamee)

President Trump threatens to invoke the Insurrection Act in Minnesota to stop protests happening in Minneapolis. And, the president unveils what he calls a new healthcare plan.

(Image credit: Octavio Jones)

A hospice in Uganda asked itself: Can we do more than ease the pain of dying? Can we actually prevent deaths from cervical and breast cancer?

(Image credit: Brian Simpson for NPR)

Breaking with the United States, Canada has agreed to cut its 100% tariff on Chinese electric cars in return for lower tariffs on Canadian farm products, Prime Minister Mark Carney said Friday.

(Image credit: Sean Kilpatrick)

See if you can get a perfect score for once.

(Image credit: Robyn Beck/AFP via Getty Images; Michael Loccisano/Getty Images; Frazer Harrison/Getty Images)

As President Trump approaches one year back in office, the policies his administration pursues — and how those policies are communicated — have been increasingly shaped by social media.

(Image credit: Mandel Ngan)