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The FDA says esketamine, an antidepressant derived from the anesthetic and party drug ketamine, can now be prescribed on its own. It was approved in 2019 to treat severe depression.

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Heavy snow, sleet and ice are making travel conditions treacherous across the region, stretching from Houston into the Florida panhandle.

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A fragile ceasefire has been in place in Gaza since Sunday, bringing an end to the fighting between Israel and Hamas at least temporarily. Some Palestinians are feeling safe enough to return to homes they fled during the way. Our producer in Gaza returns to the southern city of Rafah, the site of an intense bombing campaign. There, many are returning to their homes to find utter destruction.

For more coverage of all sides of this conflict, go to npr.org/mideastupdates

President Donald Trump has said immigration crackdowns will begin soon. It's not clear where, but in recent days Chicago has come under the spotlight. Immigrant communities in the city are bracing.

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The memo rescinds a Biden administration guideline that created "protected areas" consisting of places where "children gather, disaster or emergency relief sites, and social services establishments."

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Among his day one actions, President Trump is reviving his first-term efforts to promote classical architecture for federal buildings.

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The most "relevant" results that come up in a search of "abortion" on HHS.gov, the website for the federal Department of Health and Human Services, are several years old, from the first Trump administration.

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Trump is kicking off his second term with a flurry of executive actions. Here's a look at the three main types — orders, proclamations and memorandum — and how they typically work.

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A group of 18 state attorneys general signed on to a lawsuit filed Tuesday seeking to block the administration's move, describing it as unconstitutional.

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A winter storm prompted a National Weather Service office in Louisiana to issue a first-ever blizzard warning. The storm is causing dangerous conditions from Texas to North Carolina.

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A fire raged through a popular ski resort south of Istanbul early Tuesday. The deadly fire broke out during a school holiday when the area's hotels are packed.

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Feiffer was best known for illustrating the children's classic "The Phantom Tollbooth." His loopy lines left a lasting mark on art, literature and film.

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Elise Stefanik was a key defender of then-President Donald Trump during his impeachment proceedings and she later grilled university presidents over what she described as antisemitism.

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A new analysis suggests saber teeth were highly specialized for puncturing prey, ultimately at the cost of durability.

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Rupert Murdoch's team made the offer to resolve the hacking suits from Prince Harry and a British lawmaker as a trial was to begin. A settlement could help Washington Post CEO Will Lewis.

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After President Trump was sworn into his second term yesterday, he kept many promises and implemented key orders. He also undone several of his predecessor's actions. Here's a breakdown.

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President Trump issued a barrage of orders Monday targeting Biden-era initiatives on global warming. The decisions come on the heels of the hottest year ever recorded.

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Former district attorney Jackie Johnson is accused of interfering with the police investigation into the shooting death of Ahmaud Arbery, nearly five years after he was murdered while jogging.

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Trump closed out his appearances at both balls with his signature dance to the Village People's "YMCA," who performed the song live at the Liberty Ball.

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Afghanistan's Taliban government announced on Tuesday the release of two Americans in a prisoner exchange.

(Image credit: Anna Corbett/AP)